These two free applications will help your experience with HTC devices for Windows Mobile 6.0.  These applications give you the ability to close applications in the background with a simple click on the front screen.  Tap the X and close all background and running applications. 

This is a common problem for freezing of the handset and non-responsiveness.  Often times, windows will open up several applications in the background.  Things as simple as opening your contact list is an application called Contacts.  After a few times navigating to different things, you have 4-10 applications open and the memory on the  unit just dies.  With the memory dying, the unit will slow, freeze, and become inoperable.  

Magic button does the same but for more Windows versions and phones.

http://www.download.com/Magic-Button/3000-2178_4-10193207.html 

http://www.freewarepocketpc.net/ppc-download-htc-x-button-v1-50.html